التأثيرات المحتملة للبلميط المنشاري على حماية المعدة في قرحة المعدة الناتجة عن الإندوميتاسين في الجرذان

المؤلفون

DOI:

https://doi.org/10.32007/jfacmedbaghdad2474

الكلمات المفتاحية:

الكلمات المفتاحية: مستخلص البلميط المنشاري، أوميبرازول، قرحة المعدة، الإندوميتاسين.

الملخص

الخلفية: استخدام العقاقير المضادة للالتهابات غير الستيرويدية (مضادات الالتهاب غير الستيروئيدية) هو عامل في تطور قرحة المعدة لدى العديد من المرضى. الآلية الأساسية هي تثبيط إنزيم الأكسدة الحلقية (COX) والإجهاد التأكسدي والالتهاب.
الهدف: هدفت هذه الدراسة إلى تقييم فعالية مستخلص البلميط المنشاري ضد قرح المعدة المحدثة بالإندوميتاسين في الجرذان البيضاء.
الطرق: تم تقييم جرعة فموية من الإندوميتاسين الناجم عن قرحة المعدة، ونشاط مستخلص البلميط المنشاري من خلال تقدير تأثيره المضاد للأكسدة والمضاد للالتهابات مقارنة بالعلاج بالأوميبرازول القياسي.
النتائج: بعد جرعة الإندوميتاسين التحريضية، زادت مستويات السيتوكينات المسببة للالتهابات في المصل بشكل ملحوظ، في حين انخفضت مستويات مصل الإنزيمات المضادة للأكسدة بشكل ملحوظ. أظهر مستخلص البلميط المنشاري فعالية أكبر في تقليل مستويات السيتوكينات المسببة للالتهابات وزيادة مستويات الإنزيمات المضادة للأكسدة مقارنةً بالعلاج بالأوميبرازول الفموي القياسي.
الاستنتاجات: أثبت مستخلص البلميط المنشاري دليلاً على فعاليته كعلاج محتمل لقرحة المعدة التي تسببها الأدوية المضادة للالتهابات غير الستيرويدية (مضادات الالتهاب غير الستيروئيدية). ويرجع ذلك إلى قدرة المستخلص على تقليل الالتهاب والعمل كمضاد للأكسدة.

التنزيلات

تنزيل البيانات ليس متاحًا بعد.

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 Inflammatory response; Indomethacin; Omeprazole; Oxidative stress; Saw Palmetto Extract

التنزيلات

منشور

2025-04-01

كيفية الاقتباس

1.
Abdul Majeed ZM, Al-Atrakji MQ. التأثيرات المحتملة للبلميط المنشاري على حماية المعدة في قرحة المعدة الناتجة عن الإندوميتاسين في الجرذان. J Fac Med Baghdad [انترنت]. 1 أبريل، 2025 [وثق 24 يونيو، 2025];67(1):97-103. موجود في: https://www.iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2474

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